Table 3.

Genes exhibiting consistent relationships with inferred regulatory influences between the Calu-3 model, macaque, and mouse response data.

Symbol	ID	Description	Macaquea	Mouse
ABI3	NM_016428	ABI gene family, member 3	0.35
MXD1	NM_002357	MAX dimerization protein 1	0.35	0.53
ALOX5	NM_000698	arachidonate 5-lipoxygenase	0.36
COL4A3	NM_000091	collagen, type IV, alpha 3 (Goodpasture antigen)	0.36
C1QTNF3	NM_181435	C1q and tumor necrosis factor related protein 3	0.38
CH25H	NM_003956	cholesterol 25-hydroxylase	0.38	0.86
FOS	NM_005252	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.39
TNFSF13B	NM_006573	tumor necrosis factor (ligand) superfamily, member 13b	0.40
IL1R2	NM_004633	interleukin 1 receptor, type II	0.40	0.88
CD86	NM_006889	CD86 molecule	0.40	0.87
TNFAIP3	NM_006290	tumor necrosis factor, alpha-induced protein 3	0.41	0.70
ASCL2	NM_005170	achaete-scute complex homolog 2 (Drosophila)	0.41
IRX4	NM_016358	iroquois homeobox 4	0.41
BATF2	NM_138456	basic leucine zipper transcription factor, ATF-like 2	0.41	0.88
SCNN1G	X87160	sodium channel, nonvoltage-gated 1, gamma	0.42
PARP11	NM_020367	poly (ADP-ribose) polymerase family, member 11	0.42	0.83
CMTM2	NM_144673	CKLF-like MARVEL transmembrane domain containing 2	0.42
ADM	NM_001124	Adrenomedullin	0.43	0.77
PRSS12	NM_003619	protease, serine, 12 (neurotrypsin, motopsin)	0.44
USP18	NM_017414	ubiquitin specific peptidase 18	0.48	0.94
PI3	NM_002638	peptidase inhibitor 3, skin-derived (SKALP)	0.48
IL29	NM_172140	interleukin 29 (interferon, lambda 1)	0.54
UPP1	NM_181597	uridine phosphorylase 1	0.57	0.84
INDO	NM_002164	indoleamine-pyrrole 2,3 dioxygenase	0.58	0.90
LDHC	NM_002301	lactate dehydrogenase C	0.58
CXCL10	NM_001565	chemokine (C-X-C motif) ligand 10	0.58	0.96
RND1	NM_014470	Rho family GTPase 1	0.59	0.85
IFIT2	NM_001547	interferon-induced protein with tetratricopeptide repeats 2	0.60	0.97
IFIT1	NM_001548	interferon-induced protein with tetratricopeptide repeats 1	0.62	0.96
IFIT3	NM_001549	interferon-induced protein with tetratricopeptide repeats 3	0.64	0.97
ATF3	NM_004024	activating transcription factor 3	0.66	0.86
OASL	NM_003733	2'-5'-oligoadenylate synthetase-like	0.67
CCL4	NM_002984	chemokine (C-C motif) ligand 4	0.67	0.92
JUNB	NM_002229	jun B proto-oncogene	0.68	0.66
MX2	NM_002463	myxovirus (influenza virus) resistance 2	0.69	0.90
XAF1	NM_017523	XIAP associated factor-1	0.70
IL6	NM_000600	interleukin 6 (interferon, beta 2)	0.71	0.92
RSAD2	NM_080657	radical S-adenosyl methionine domain containing 2	0.89	0.85
OAS2	NM_016817	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.92	0.84

^a Xpred scores from Calu-3 model cross-predictions in macaque and mouse. Bold indicates statistical significance (p-value < 0.05)