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Kinetic parameters determined for 4-OH-RA and 18-OH-RA formation by CYP26A1 and CYP26B1.
| CYP26A1 | CYP26A1 | CYP26B1 | |
|---|---|---|---|
| 4-OH RA | 18-OH RA | 4-OH RA | |
| KM (nM) | 50.1 ± 32.4 | 48.9 ± 13.4 | 18.8 ± 18.7 |
| Vmax (pmol/min/pmol P450) | 9.5 ± 2.2 | 5.0 ± 0.5 | 0.81 ± 0.2 |
| Clint (µL/min/pmol P450) | 190 | 102 | 43 |
