Table 3.
Change in cooperativity, ηrel
| Combination | Virus | ||||||
|---|---|---|---|---|---|---|---|
| R5 | X4 | ||||||
| CC1/85 | 9-6 | 9-7 | 9-8 | IIIB | LAI | NL4.3 | |
| VCV + PRO 140 | 1.8±0.11 | 1.5±0.060 | 2.0±0.19 | 1.4±0.15 | - | - | - |
| VCV/AMD3100 + T-20 | 1.5±0.15 | 1.4±0.045 | 1.4±0.089 | 1.2±0.092 | 1.2±0.13 | 1.2±0.033 | 1.0±0.079 |
| VCV/AMD3100 + Nevirapine | 1.2±0.034 | 1.1±0.072 | 1.0±0.017 | 1.1±0.038 | 1.2±0.064 | 1.0±0.20 | 1.0±0.050 |
| CD4-IgG2 + 17b | 1.3±0.16 | 1.0±0.14 | 1.2±0.068 | 1.6±0.27 | 1.4±0.16 | 1.3±0.083 | 1.1±0.047 |
| b12 + 2G12 | 1.2±0.048 | 1.1±0.030 | 1.1±0.042 | 1.2±0.11 | 1.6±0.060 | 1.2±0.077 | 1.1±0.046 |
| b12 + 2F5 | 1.1±0.130 | 1.4±0.28 | 1.1±0.019 | 0.93±0.057 | 1.2±0.096 | 1.0±0.048 | 1.1±0.052 |
| b12 + 17b | 1.0±0.30 | 1.0±0.078 | 1.0±0.043 | 1.1±0.075 | 1.3±0.132 | 1.1±0.048 | 1.2±0.039 |
| 2G12 + 2F5 | 1.6±0.30 | 1.6±0.34 | 1.4±0.15 | 1.6±0.32 | 1.7±0.191 | 1.5±0.0081 | 1.4±0.23 |
| 2G12 + 17b | 1.6±0.17 | 1.8±0.16 | 1.3±0.077 | 1.8±0.077 | 1.4±0.065 | 1.5±0.35 | 1.3±0.099 |
| 2F5 + 17b | 1.3±0.19 | 1.2±0.11 | 1.1±0.13 | 1.2±0.118 | 1.3±0.091 | 0.9±0.12 | 1.3±0.058 |
a
The values are the mean values of fold change in η (calculated as ηrel = ((ηAB/ηA) + (ηAB/ηB))/2) from n (3 ≤ n ≤ 9) replicate experiments ± SEM. Mean values of ηrel + 2 SEM > 1 are given in bold. There were no mean values of ηrel + 2 SEM < 1. Note that n for each combination of inhibitors and virus is the same as in Table 2 and is given only there.