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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Clin Cancer Res. 2011 Sep 8;17(23):7359–7372. doi: 10.1158/1078-0432.CCR-11-1388

Figure 3. Status of PI3K/AKT/mTOR signaling in murine ovarian cancer cells determines response to Akt and mTOR inhibitors, but not to conventional cytotoxic drugs.

Figure 3

Growth inhibitory effects of A) rapamycin, B) cisplatin, C) paclitaxel, and D) perifosine were evaluated in W2671T, W2830T and ID8 cells in vitro. After exposure to indicated drugs or controls for 24 hr, cell viability was measured with WST-1 reagent. Proportional viability (%) was calculated by comparing the drugs with vehicle controls, whose viability was assumed to be 100%. Values represent the average of three independent assays performed in duplicate, expressed as means ± SD. Differences between control and treated cells were analyzed by one way ANOVA.