Fig. 1.

Molecular structure of Fmi/Celsr family members. Flamingo and Celsr extracellular domains comprises nine cadherin repeats, a series of EGF-like and laminin globular-like domains, and a hormone receptor domain (HRM). The seven-transmembrane domain, similar to those found in GPCRs, is characteristic of this atypical cadherin subfamily. The GPCR proteolytic site (GPS) is conserved in many adhesion GPCRs. The intracellular domain is generally not conserved and does not contain recognizable domains. Adapted from [2]