Table 1.

Insulin glulisine dose titration

Russia and United Kingdom
Calculation of the initial dose of insulin glulisine for the first injection:
Dose of insulin glulisine prior to the main meal = PPBG of the main meal in mmol/l divided by 2
Treat to target: PPBG ≤135 mg/dl (7.5 mmol/l)
PPBG ≤135 mg/dL (7.5 mmol/l)	No change
135 mg/dl (7.5 mmol/l) <PPBG ≤153 mg/dl (8.5 mmol/l)	+1 U
153 mg/dl (8.5 mmol/l) <PPBG ≤80 mg/dl (10 mmol/l)	+2 U
PPBG >180 mg/dl (10 mmol/l)	+3 U
At the discretion of the investigator, small decreases of 1 U of the dose of insulin glulisine are permitted in case of hypoglycaemia
United States
Calculation of the initial dose of insulin glulisine for the first injection:
6 U prior to the main meal. At the same time, the insulin glargine dose was reduced by 6 U and then titrated again the next week
Treat to target: 100 mg/dl (5.6 mmol/l) <BG*≤120 mg/dl (6.7 mmol/l)
120 mg/dl (6.7 mmol/l) <BG*≤140 mg/ dl (7.8 mmol/l)	+1 U
140 mg/dl (7.8 mmol/l) <BG*≤180 mg/ dl (10 mmol/l)	+2 U
BG* >180 mg/dl (10 mmol/l)	+2 U
At the discretion of the investigator, small decreases of 1 U of the dose of insulin glulisine are permitted in case of hypoglycaemia

^*Pre-meal or bedtime BG value. FPG, fasting plasma glucose; PPBG, postprandial blood glucose; BG, blood glucose.