Table 2.
Candidate gene targets identified in this study.
| Gene | Name | miRNA species |
|---|---|---|
| BAI3 | brain-specific angiogenesis inhibitor 3 | miR-922; miR-548b-5p; miR-548c-5p |
| GK | glycerol kinase | miR-571; miR-548b-5p; miR-548c-5p |
| SLC23A2 | solute carrier family 23 (nucleobase transporters), member 2 | miR-922; miR-548b-5p; miR-548c-5p |
| GTDC1 | glycosyltransferase-like domain containing 1 | miR-516a-3p; miR-571 |
| CNR1 | cannabinoid receptor 1 | miR-548b-5p; miR-548c-5p |
| FAM134B | family with sequence similarity 134, member B | miR-548b-5p; miR-548c-5p |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | miR-548b-5p; miR-548c-5p |
| MYT1L | myelin transcription factor 1-like | miR-548b-5p; miR-548c-5p |
| NCAM1 | neural cell adhesion molecule 1 | miR-548b-5p; miR-548c-5p |
| TMEM135 | transmembrane protein 135 | miR-548b-5p; miR-548c-5p |
| ATP8A1 | ATPase, class I, type 8A, member 1 | miR-922 |
| KCNAB1 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | miR-922 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | miR-922 |
| RASA1 | RAS p21 protein activator 1 | miR-922 |
| REEP1 | receptor accessory protein 1 | miR-922 |
| SNCA | synuclein, alpha | miR-922 |
| A2BP1 | ataxin-2-binding protein 1 | miR-516a-3p |
| ASTN1 | astrotactin 1 | miR-516a-3p |
List of top scoring genes predicted to be regulated by the 5 significantly upregulated miRNAs (miR-922, miR-516a-3p, miR-571, miR-548b-5p, and miR-548c-5p) from the 177 mRNAs significantly downregulated in frontal cortex and cerebellum in PGRN+ compared to PGRN- FTLD-TDP patients (GEO record GDS3459).