Table 1.
Traditional aim of animal model | Aim of animal model in this review |
---|---|
Face validity: mimics the fundamental behavioural characteristics | Treatment validity: predicts the clinical effectiveness of a new compound. |
Construct validity: expresses the known aetiology and pathophysiology | May or may not have face validity |
Predictive validity: Predicts novel biology or clinical observations | May or may not have construct validity |
May or may not display expected effects of proven treatments. |