Scheme 1.
Reagents and conditions: a) NR1R2, EtOH/iPrOH, 80 °C, 18 h; b) MsCl/Et3N, 0 °C, 2 h; c) MeNH2, RT, 16 h; d) Bromotrispyrrolidinophosphonium hexafluorophosphate (PyBrop), Et3N, CH2Cl2, 30 min.
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