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. 2011 Aug 10;6(10):1832–1840. doi: 10.1002/cmdc.201100278

Table Table 1.

Structure and EC50 values for (+)-(1R,2R)-U50488 and related compounds

Inline graphic
Compd Stereochemistry EC50 [μm]
T. brucei MRC-5
1 R,R (+) 0.028[a] 44
2 S,S (−) 9.9 48
3 R,R/S,S (±) 0.052 40
[a]

Data acquired with our 384-well format assay (see Experimental Section), which is similar to data acquired with the original 96-well format assay.[4]