Table 1.
Demographic and medical characteristics by depression group (N=766)*
| Characteristic | No Depression (n=408) |
Minor Depression (n=195) |
Major Depression (n=163) |
P-value |
|---|---|---|---|---|
| Demographics | ||||
| Gender (% Female) | 131 (32.1) | 89 (45.6) | 84 (51.5) | <.001 |
| Caucasian | 322 (78.9) | 144 (73.9) | 114 (70.0) | .06 |
| Married | 312 (78.0) | 117 (62.2) | 86 (54.4) | <.001 |
| Education (> 12 years) | 304 (77.0) | 130 (69.5) | 108 (68.8) | .06 |
| Medical | ||||
| Heart Rate at Baseline (bpm) | 71.2 ± 12.4 | 73.0 ± 13.6 | 75.4 ± 12.6 | .002 |
| Systolic blood pressure (mmHg) | 122.2 ± 18.1 | 124.6 ± 20.9 | 121.7 ± 18.6 | .27 |
| Body Mass Index (kg/m2) | 28.4 ± 4.8 | 29.4 ± 5.9 | 29.5 ± 6.3 | .04 |
| Cigarette smoker (current) | 104 (26.1) | 69 (35.8) | 75 (46.6) | <.001 |
| Total Cholesterol (mg/dl) | 184.3 ± 47.3 | 199.1 ± 45.7 | 192.1 ± 45.7 | .007 |
| Time from MI to Baseline (days) | 17.1 ± 6.5 | 7.9 ± 6.1 | 8.4 ± 7.0 | <.001 |
| Post MI PTCA | 270 (67.3) | 107 (56.0) | 94 (58.4) | .01 |
| Thrombolytic therapy | 135 (33.6) | 59 (31.1) | 40 (25.0) | .14 |
| < 24 hr admit from index MI | 309 (76.5) | 153 (79.3) | 131 (81.9) | .35 |
| History hypercholesterdemia | 195 (49.1) | 123 (66.5) | 96 (61.2) | <.001 |
| Heart disease in 1st degree relatives | 268 (67.2) | 119 (64.0) | 110 (71.0) | .39 |
| History PVD | 22 (5.6) | 19 (10.4) | 33 (20.9) | <.001 |
| History CABG | 42 (10.4) | 21 (11.2) | 19 (12.0) | .87 |
| History PTCA | 41 (10.3) | 32 (17.2) | 30 (18.9) | .009 |
| History of Hypertension | 211 (52.4) | 114 (59.7) | 97 (61.0) | .09 |
| Charlson Comorbidity Index | 1.6 ± 1.8 | 2.1 ± 2.0 | 2.5 ± 2.2 | <.001 |
| ENRICHD All-Cause Mortality Risk Score1 | ||||
| Age (years) (766) | 61.1 ± 10.6 | 58.3 ± 12.3 | 55.3 ± 12.5 | <.001 |
| Diabetes mellitus (761) | 91 (22.3) | 56 (29.0) | 60 (37.5) | .001 |
| LVEF (<40%) (581) | 82 (23.0) | 41 (23.3) | 37 (24.5) | .93 |
| Killip class III-IV (725) | 17 (4.4) | 6 (3.3) | 15 (9.7) | .02 |
| Creatinine (≥ 1.3 mg/dl) (729) | 87 (22.3) | 26 (14.1) | 29 (19.0) | .07 |
| Post MI CABG (752) | 52 (13.0) | 32 (16.7) | 19 (11.8) | .36 |
| History CHF (690) | 16 (4.4) | 20 (11.4) | 32 (20.9) | <.001 |
| Previous AMI (743) | 81 (20.3) | 43 (23.0) | 33 (21.2) | .75 |
| History Stroke/TIA (741) | 23 (5.8) | 22 (11.8) | 17 (10.9) | .02 |
| Total Weighted Score (459) | 3.68 ± .88 | 3.65 ± 1.03 | 3.68 ± 1.10 | .96 |
| Medications | ||||
| Beta blocker | 332 (85.4) | 151 (79.5) | 124 (78.0) | .06 |
| ACE inhibitor | 197 (50.0) | 85 (44.7) | 77 (48.4) | .49 |
| Aspirin | 355 (90.1) | 175 (93.1) | 133 (84.7) | .03 |
| Depression | ||||
| Baseline BDI Depression Score | 3.9 ± 2.9 | 14.3 ± 5.4 | 21.4 ± 8.2 | <.001 |
| Probable # of Prior Major Depressive Episodes | .3 ± .9 | 3.0 ± 6.4 | 2.3 ± 3.6 | <.001 |
| History of Depression | 56 (16.1) | 186 (96.4) | 124 (76.5) | <.001 |
| History of Antidepressants | 7 (1.8) | 29 (15.3) | 22 (13.8) | <.001 |
| Family History of Depression | 47 (14.9) | 79 (44.4) | 62 (40.8) | <.001 |
*
Continuous variables are reported as mean ± SD; categorical variables represent number of patients (%).
1
Number in the last parenthesis represents the number of patients with observed data for that particular risk score element.