Table 2. CpG sites with the most significant age-associated changes.

Reference ID	Gene	Age-associated R-values
all samples of training group	dermis	epidermis	cervical smear	CD14+ monocytes	CD4+ T-cells
Pavlidis Template Matching was used to identify CpG sites with the most significant age-associated changes. 19 CpG sites revealed hypermethylation with a Pearson correlation coefficient R of > 0.6 in all samples of the training group. Significant age-associated correlations were also observed in most individual datasets. CpG sites of the Epigenetic-Aging-Signature are indicated in grey. *One additional hypomethylated CpG site (cg23571857) was included in the predictor.
cg06572160	KCNC3	0.70	0.73	0.87	0.24	0.41	0.50
cg07533148	TRIM58	0.69	0.68	0.76	0.35	0.38	0.52
cg20616414	WNK2	0.67	0.66	0.87	0.31	0.32	0.33
cg17861230	PDE4C	0.67	0.92	0.91	0.42	0.38	0.22
cg25302419	CTNND2	0.67	0.65	0.68	0.33	0.59	0.55
cg25802093	SPAG6	0.64	0.63	0.82	0.34	0.31	0.72
cg06458239	ZNF549	0.63	0.88	0.85	0.15	−0.13	0.45
cg27009703	HOXA9	0.63	0.66	0.90	0.29	0.30	0.56
cg02844545	GCM2	0.63	0.75	0.77	0.35	0.66	0.47
cg01683883	CMTM2	0.63	0.83	0.80	0.17	−0.18	0.21
cg01530101	KCNQ1DN	0.63	0.91	0.67	0.16	0.33	0.45
cg12799895	NPTX2	0.62	0.78	0.75	0.04	0.46	0.35
cg21907579	TBX5	0.62	0.74	0.73	0.25	0.21	0.35
cg00107187	FLJ42486	0.62	0.89	0.65	0.25	0.45	0.44
cg16313343	BRF1	0.62	0.79	0.74	0.17	−0.12	0.25
cg25148589	GRIA2	0.62	0.90	0.91	0.52	0.25	0.34
cg23290344	NEF3	0.61	0.68	0.71	0.26	0.44	0.52
cg02681442	FOXG1B	0.60	0.68	0.79	0.08	0.35	0.41
cg03158400	FAM3B	0.60	0.71	0.70	0.37	0.13	0.66
cg23571857	BIRC4BP	−0.45*	−0.66	−0.84	−0.18	−0.11	−0.40