Table 6.
Platelet factor 4 (PF4) and growth factors in releasates, platelet lysates, platelet-poor plasma (PPP), and serum in 14 patients with osteonecrosis (ON) and in 10 controls (Ctr). Releasates and lysates were obtained from platelet concentrates, after adjustment of platelet number to 1 × 106 / mL
| Sample | PF4 (IU/mL) | TGF-β1 (ng/mL) | PDGF-BB (ng/mL) | VEGF-A (pg/mL) | ||||
|---|---|---|---|---|---|---|---|---|
| ON | Control | ON | Control | ON | Control | ON | Control | |
| Releasates | ||||||||
| mean (SD) | 7,661 (2,648) | 6,856 (2,171) | 55 (76) | 28 (35) | 8.1 (3.5) | 6.4 (2.6) | 165 (83) | 105 (88) |
| median | 8,265 | 6,939 | 21 | 16 | 8.1 | 6.5 | 183 | 105 |
| range | 4,568–10,000 | 3,269–10,000 | 2–200 | 2–105 | 2.9–13.7 | 2.5–11.1 | 9–235 | 9–230 |
| Lysates | ||||||||
| mean (SD) | 8,621 (3,231) | 9,042 (1,670) | 146 (85) | 99 (68) | 11.9 (7.4) | 10.8 (6.3) | 206 (180) | 172 (134) |
| median | 10,000 | 10,000 | 200 | 69 | 11.1 | 9.2 | 152 | 138 |
| range | 2,031–10,000 | 4,717–10,000 | 33–200 | 26–196 | 2.7–26.8 | 4–26 | 9–570 | 9–402 |
| Serum | ||||||||
| mean (SD) | 7,405 (985) a | 5,142 (1240) | 38 (18) | 26 (15) | 4.2 (3.6) b | 2.3 (0.5) | 215 (210) | 182 (134) |
| median | 7,383 | 4,697 | 50 | 29 | 3.1 | 2.2 | 155 | 160 |
| range | 5,777–8,553 | 3,576–7,165 | 14.6–50 | 2.5–50 | 1.1–13.5 | 1.3–3.1 | 9–628 | 9–493 |
a p = 0.005 when compared with controls;
b p = 0.02 when compared with controls.