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. 2011 Aug 30;152(12):5053–5064. doi: 10.1210/en.2011-1372

Fig. 4.

Fig. 4.

Localization of Mct8 in the cochlea. Left panels, In situ hybridization of Lat1 mRNA in the greater epithelial ridge (ger) (A), sensory epithelium region (C), and stria vascularis (stv)/spiral ligament (sl) (E). Right panels, Similar regions showing immunofluorescence for Mct8 protein (red) and CD31 endothelial marker (green). A, Mct8 mRNA signal in ger at P3. B, Mct8 protein localized to ger but not to CD31-positive blood vessels. Mct8 protein localized to the cell membrane of columnar cells of the ger. C, Mct8 mRNA signal in tympanic border cells (tbc) at P15. ohc, Outer hair cells. D, Mct8 protein localized to tbc and not to CD31-positive vessels (arrowhead). Mct8 protein localized to the cell membrane in tbc. E, Mct8 mRNA signal in stv and sl at P15 (dashed line, boundary between stv and sl). Arrowheads, Blood vessels; arrows, sl fibrocytes. F, Mct8 immunofluorescence (red) although weak, localized to the abluminal side of CD31-positive blood capillaries (arrowhead, green) in stv. In the sl, Mct8 protein was detected widely in fibrocytes (red) and not in CD31-positive vessels (green). spv, Spiral vessel; DAPI, 4′,6-diamidino-2-phenylindole.