Fig. 2.

Change from baseline in average core temperature after microinfusion of 90 pmol senktide or vehicle (aCSF) in the MnPO of OVX + E₂ and OVX rats (ambient temperature of 21.5 C, n = 6–8 microinfusions/group). Senktide resulted in a significant decrease in core temperature that was similar in OVX + E₂ and OVX rats. The horizontal line represents the average baseline value of all groups. #, Significantly different, senktide compared with vehicle, OVX + E₂ rats; *, significantly different, senktide compared with vehicle, OVX rats; +, significantly different from time 0 in OVX + E₂ vehicle-microinfused rats; five-pointed star, significantly different from time 0 in OVX vehicle-microinfused rats.