Fig. 3.

Change from baseline in average core temperature after microinfusion of 90 pmol senktide or vehicle in the MnPO of OVX + E₂ rats at ambient temperatures of 21.5 or 29.0 C (n = 6–8 microinfusions/group). The data from OVX + E₂ rats at the ambient temperature of 21.5 C is duplicated from Fig. 2 to facilitate comparisons. Senktide microinfusion resulted in a significant decrease in core temperature (compared with vehicle) in rats exposed to ambient temperatures of both 21.5 and 29.0 C. At the ambient temperature of 29.0 C, the hypothermia induced by senktide was prolonged. The horizontal line represents the average baseline value of all groups. #, Significantly different, senktide compared with vehicle, ambient temperature of 21.5 C; *, significantly different, senktide compared with vehicle, ambient temperature of 29.0 C; five-pointed star, significantly different, senktide at ambient temperature of 29.0 C, vs. senktide at ambient temperature of 21.5 C; +, significantly different from time 0 in vehicle-microinfused rats, ambient temperature of 21.5 C.