Table 1.

Summary of microinfusion experiments

Dose (300-nl solution)	Estrogen status	TAMBIENT	Thermoregulatory Evaluation	Evaluation of brain histology
18 or 90 pmol senktide or vehicle	OVX + E2	21.5 C	TCORE	Nissl stain
90 pmol senktide or vehicle	OVX + E2	21.5 C	TCORE, TSKIN, and behavior	Terminal fluorescent dextran, Nissl stain, and dual-label Fos-NK3R immunohistochemistry
90 pmol senktide or vehicle	OVX + E2	29.0 C	TCORE and TSKIN	Terminal fluorescent dextran and Nissl stain
90 pmol senktide or vehicle	OVX	21.5 C	TCORE, TSKIN, and behavior	Terminal fluorescent dextran and Nissl stain

n = 6–8 microinfusions/group. T_CORE, Core temperature; T_SKIN, tail skin temperature.