Fig. 6.

Effect of the synthetic LXR agonist, GW3965, on bone, in vivo. Six-week-old female C57BL/6 mice were treated sc with 30 mg/kg·d for 28 d. A, μCT analysis of femurs indicating total BV/TV, trabecular number (Tb#), trabecular thickness, trabecular separation, and cortical thickness. B, Histomorphometric analysis of femora. Sections were stained with Goldner's trichrome stain and analyzed at ×20 magnification. C, Calvarial mRNA expression as determined by QPCR. D, Serum osteocalcin and urine DPD. OPG, Osteoprotegrin. Different letters denote statistical significance (P < 0.05).