Fig. 4.

Oocyte-specific restoration of JAGGED1 expression, via lentiviral-mediated gene transfer, rescues the deficit in follicle growth of TrkB^−/− ovaries. A, Increased number of secondary follicles in TrkB^−/− ovaries incubated for 4 d with LV-Jagged1 in comparison with TrkB^−/− ovaries infected with LV-no Jagged1. B, Section from a TrkB^−/− ovary infected with LV-no Jagged1. C, Section from a TrkB^−/− ovary infected with LV-Jagged1. Arrows point to secondary follicles, which contain an oocyte surrounded by two layers of GC. Scale bar, 50 μm. Columns represent the mean of four mice per group, and vertical lines are sem. One ovary from each animal was infected with LV-Jagged1 and the contralateral ovary from the same animal with LV-no Jagged1. *, P < 0.05.