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. 2011 Oct 4;152(12):4800–4812. doi: 10.1210/en.2011-1542

Fig. 1.

Fig. 1.

Regulation of pituitary somatotrope, lactotrope, and corticotrope cell axes in male and female wild-type (cort+/+, open columns) vs. cort−/− (black columns) mice. A, Basal GH release (left), GH expression (middle), and circulating IGF-I levels (right). B, Growth curves from males and females cort+/+ (solid lines) and cort−/− (dotted line) littermates from 4 to 13 wk of age. C, Basal PRL release (left), PRL expression (middle), and percentage of survival of the first litter of female cort+/+ (open column) vs. cort−/− (solid column) mice (right). D, Basal PRL release in a second group of male and female cort+/+ (open columns) and cort−/− (black columns) as compared with male and female sst+/+ (open columns) and sst−/− (gray columns). E, Basal PRL levels in 7 d vehicle-infused (Veh) and CST14-infused (CST) female cort+/+ and cort−/− mice via sc osmotic pumps. F, Basal ACTH hormone release (left), POMC expression (middle), and circulating corticosterone levels (right). Values represent mean ± sem (six to seven mice/genotype per gender) of hormonal circulating levels or absolute hormone mRNA copy numbers (adjusted by NF). Percentages of litter survival from female mice are expressed as mean ± sem (n = 11–37 breeders). Asterisks indicate values that significantly differ from their controls (cort+/+ or sst+/+) (*, P < 0.05; **, P < 0.01; ***, P < 0.001).