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. 2011 Oct 4;152(12):4800–4812. doi: 10.1210/en.2011-1542

Fig. 5.

Fig. 5.

Impact of lack of endogenous CST or SST on glucose homeostasis. Circulating insulin levels in male and female cort+/+ (white columns) vs. cort−/− (gray columns) (A) and sst+/+ (white columns) vs. sst−/− (gray columns) (D) mice. GTT (top) and ITT (bottom) of male (right) and female (left) cort+/+ (solid lines) vs. cort−/− (dotted lines) mice (B) and of male (right) and female (left) sst+/+ (solid lines) vs. sst−/− (dotted lines) mice (E). Area under curve (AUC) of GTT (top) and ITT (bottom) conducted in male and female cort+/+ (white columns) vs. cort−/− (gray columns) mice (C) and of male and female sst+/+ (white columns) vs. sst−/− (gray columns) mice (F). GTT and ITT were performed as we previously reported (26). Values are represented as the means ± sem (n = 6–12 mice/genotype per gender). Asterisks (*, P < 0.05; **, P < 0.01; ***, P < 0.001) indicate values that significantly differ from cort+/+ (A–C) or sst+/+ (D and E) within gender.