Skip to main content
. 2011 Oct 5;31(40):14436–14449. doi: 10.1523/JNEUROSCI.3836-11.2011

Figure 5.

Figure 5.

CORT treatment does not mimic chronic stress-induced tau hyperphosphorylation in PS19 mice. A, Experimental design of experiment 3; PS19 male mice were not stressed but were administered CORT pellets (n = 8 per group). B, First, a small pilot (n = 3 per group) of adult WT male mice were implanted with CORT pellets (arrows) to assess the plasma hormone levels achieved by these pellets. A high spike in CORT within the first 72 h was significantly higher (F(2,7) = 2.25, p < 0.0001) than after an acute stress from experiment 1 (data also shown in Fig. 4A). Furthermore, neither representative images of AT8-IR in the hippocampus (C) nor IR quantification using a semiquantitative rating scale (0–5) (D) showed a treatment difference. AU, Arbitrary units; Veh, vehicle. Data show mean ± SEM AT8 score. E, A representative Western blot probed for both PHF1, 17025, and GAPDH as a loading control also demonstrate no difference after CORT treatment in the hippocampus. Scale bar, 0.5 mm.