Table 1.

Mean values for gravimetric measures in post hoc comparison groups.

Parameter	Group [(Young/Aged)-(Control/SSW)-(Wild-type/CCM)]
	Y-C-W	Y-S-W	A-C-W	A-S-W	Y-C-C	Y-S-C	A-C-C	A-S-C
BW (g)	32.4 ± 1.6	31.0 ± 2.2	38.1 ± 2.5	36.6 ± 1.6#	27.8 ± 1.7	32.4 ± 1.6$	34.0 ± 2.6#	35.8 ± 1.6
LW (mg)	156 ± 8	147 ± 11	197 ± 23#	241 ± 57	170 ± 6	150 ± 10	197 ± 11#	166 ± 19
KW (mg)	226 ± 15	241 ± 22	269 ± 11	278 ± 11	231 ± 8	220 ± 16	269 ± 23	243 ± 11
EFW (g)	0.94 ± 0.12	1.01 ± 0.11	1.35 ± 0.15	1.53 ± 0.18#	0.49 ± 0.15*	1.00 ± 0.15$	1.06 ± 0.19#	1.41 ± 0.17
BVW (mg)	173 ± 11	145 ± 6	183 ± 16	193 ± 14#	198 ± 9	198 ± 19*	215 ± 19	212 ± 11
BVW/BW (mg/g)	5.36 ± 0.31	4.69 ± 0.17	4.78 ± 0.11	5.36 ± 0.55	7.27 ± 0.55*	6.08 ± 0.40*	6.37 ± 0.59*	5.93 ± 0.32

Definitions include: Y, young (6 month old) mice; A, aged (22 month old) mice; C, control light/dark cycle; S, simulated shift work (i.e., repetitive reversal of the light/dark cycle for 4 months); W, wild-type mice; C, cardiomyocyte-specific circadian clock mutant (CCM) mice; SSW, simulated shift work, light/dark cycle manipulation; BW, body weight; LW, lung weight; KW, kidney weight; EFW, epididymal fat weight, BVW, bi-ventricular weight; NS, not significant. Values are expressed as mean ± SEM (n=3–7).

^#denotes p<0.05 for young versus aged hearts within the same light/dark cycle and genotype groups.

^$denotes p<0.05 for control versus SSW hearts within the same age and genotype groups.

^*denotes p<0.05 for wild-type versus CCM hearts within the same age and light/dark cycle groups.