Table 2.
Mean values for humoral factors in post hoc comparison groups.
| Parameter | Group [(Young/Aged)-(Control/SSW)-(Wild-type/CCM)] | |||||||
|---|---|---|---|---|---|---|---|---|
| Y-C-W | Y-S-W | A-C-W | A-S-W | Y-C-C | Y-S-C | A-C-C | A-S-C | |
| Glucose (mg/dl) | 401 ± 29 | 238 ± 38$ | 370 ± 36 | 366 ± 31# | 327 ± 32 | 243 ± 42 | 335 ± 47 | 313 ± 35 |
| Triglyceride (mg/dl) | 99 ± 18 | 100 ± 24 | 93 ± 23 | 237 ± 47$ | 90 ± 31 | 217 ± 71 | 155 ± 24 | 175 ± 22 |
| Insulin (ng/ml) | 0.65 ± 0.10 | 0.38 ± 0.16 | 0.75 ± 0.26 | 1.72 ± 0.73 | 0.52 ± 0.11 | 0.74 ± 0.25 | 0.54 ± 0.11 | 0.49 ± 0.13 |
| Leptin (ng/ml) | 7.9 ± 1.3 | 9.8 ± 3.1 | 18.5 ± 9.2 | 13.9 ± 3.4 | 5.3 ± 1.0 | 20.4 ± 6.7 | 8.8 ± 1.2 | 11.3 ± 3.4 |
| Adiponectin (μg/ml) | 5.0 ± 0.6 | 4.5 ± 0.5 | 5.5 ± 0.8 | 4.4 ± 0.3 | 4.6 ± 0.6 | 5.0 ± 0.6 | 4.7 ± 0.6 | 4.3 ± 0.7 |
| Corticosterone (ng/ml) | 282 ± 16 | 312 ± 22 | 249 ± 23 | 327 ± 22$ | 246 ± 24 | 344 ± 35 | 257 ± 18 | 280 ± 37 |
Definitions include: Y, young (6 month old) mice; A, aged (22 month old) mice; C, control light/dark cycle; S, simulated shift work (i.e., repetitive reversal of the light/dark cycle for 4 months); W, wild-type mice; C, cardiomyocyte-specific circadian clock mutant (CCM) mice; SSW, simulated shift work, light/dark cycle manipulation; NS, not significant. Values are expressed as mean ± SEM (n=3–7).
#
denotes p<0.05 for young versus aged hearts within the same light/dark cycle and genotype groups.
$
denotes p<0.05 for control versus SSW hearts within the same age and genotype groups.