Skip to main content
. Author manuscript; available in PMC: 2011 Dec 5.
Published in final edited form as: Mol Immunol. 2008 Jul 30;45(15):4036–4039. doi: 10.1016/j.molimm.2008.06.013

Figure 1.

Figure 1

Reconstitution of normal human IgM in RAG-1−/− mice induces local tissue injury in murine intestinal I/R model. Normal human IgM were purified by IgM affinity chromatography and reconstituted into RAG-1−/− mice (i.v. 50ug per animal) 30min prior to surgery. IgM reconstituted mice were divided into either sham or I/R treated groups. The I/R treated mice were undergone 40min intestinal ischemia followed by 3h reperfusion. Intestinal tissues were harvested and stained with H&E. The morphological injuries of intestine were quantified by an established pathology score system (Magnification=200×). Each symbol represents an individual mouse reconstituted with natural IgM from an individual human donor. The horizontal bars represent the arithmetic means of the injury scores. Asterisks indicate statistical significance (student t-test; p<0.05).