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. Author manuscript; available in PMC: 2012 Dec 15.

Published in final edited form as: Anal Biochem. 2011 Aug 16;419(2):106–109. doi: 10.1016/j.ab.2011.08.018

Fig. 2 — Ex-vivo determination of plasma D-serine by the SPE/DAAO method after oral administration of D-serine ± DAAO inhibitors - CD1 mice were given D-serine (326 μmoles/kg, po) ± DAAO inhibitors CBIO (180 μmoles/kg) or TPC (160 μmoles/kg). Plasma was collected at 0.5, 1, 2, 3, and 6 hours after dosage. D-serine was extracted from plasma by SPE and its levels determined by the DAAO reaction: (A) D-serine alone, (B) CBIO alone, D-serine ± CBIO and (C) D-serine ± TPC. IC₅₀ values for CBIO [6] and TPC [13] were averaged from those listed in the literature. Each data point is the average of data from 3 separate mice; error bars correspond to ± S.E.M. D-serine standard curves were constructed for each experiment.

Fig. 2 — Ex-vivo determination of plasma D-serine by the SPE/DAAO method after oral administration of D-serine ± DAAO inhibitors - CD1 mice were given D-serine (326 μmoles/kg, po) ± DAAO inhibitors CBIO (180 μmoles/kg) or TPC (160 μmoles/kg). Plasma was collected at 0.5, 1, 2, 3, and 6 hours after dosage. D-serine was extracted from plasma by SPE and its levels determined by the DAAO reaction: (A) D-serine alone, (B) CBIO alone, D-serine ± CBIO and (C) D-serine ± TPC. IC₅₀ values for CBIO [6] and TPC [13] were averaged from those listed in the literature. Each data point is the average of data from 3 separate mice; error bars correspond to ± S.E.M. D-serine standard curves were constructed for each experiment.