Skip to main content
. 2010 Dec 1;10(11):1147–1156. doi: 10.4161/cbt.10.11.13447

Figure 3.

Figure 3

Expression of histone H3, cyclin E and cdc25C in SW480 cells after MMR recognition of 5-FU. (A) Effectiveness of siRNA knockdown of hMLH1 or hMSH2 proteins. (B) Histone H3 expression and knockdown of hMLH1 or hMSH2. Note the decrease in histone H3 expression with 5-FU treatment and its preservation with knockdown of hMLH1 but not with knockdown of hMSH2. (C) Cyclin E expression and knockdown of hMLH1 or hMSH2. Note the increase in cyclin E expression with 5-FU treatment and its partial reduction with knockdown of hMLH1 but not with knockdown of hMSH2. (D) Cdc25C expression and knockdown of hMLH1 or hMSH2. Decreased cdc25C expression with 5-FU treatment was not restored by knockdown of either hMLH1 or hMSH2.