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. 2010 Dec 1;10(11):1147–1156. doi: 10.4161/cbt.10.11.13447

Figure 4.

Figure 4

Expression of histone H3, cyclin E and cdc25C in HT29 cells after MMR recognition of 5-FU. (A) Effectiveness of siRNA knockdown of hMLH1 or hMSH 2 proteins. (B) Histone H3 expression and knockdown of hMLH1 or hMSH2. Note the decrease in histone H3 expression with 5-FU treatment and its partial restoration with knockdown of hMLH1 but not with knockdown of hMSH2. (C) Cyclin E expression and knockdown of hMLH1 or hMSH2. Note the increase in cyclin E expression with 5-FU treatment and its partial reduction with knockdown of hMLH1 or hMSH2. (D) cdc25C expression and knockdown of hMLH1 or hMSH2. Knockdown of either hMLH1 or hMSH2 did not restore decreased cdc25C expression by 5-FU.