Table 4.
8b2 | 8b2 + docetaxel | 1-INT | 1-INT + docetaxel | |||||
Gene | Affy | QPCR | Affy | QPCR | Affy | QPCR | Affy | QPCR |
SERPINE1 | −11.2 | −4.55 ± 0.3, p < 0.0001 | −15.62 | −18.89 ± 2.1, p < 0.0001 | −8.04 | −6.86 ± 1.25, p = 0.0005 | −12.75 | −12.53 ± 1.45, p = 0.0001 |
CXCL5 | −4.04 | −3.0 ± 0.24, p = 0.0132 | −5.11 | −3.8 ± 0.15, p < 0.0001 | −3.11 | −2.47 ± 0.13, p = 0.0023 | −4.3 | −2.71 ± 0.44, p < 0.0001 |
TGFBI | −7.38 | −6.9 ± 2.32, p = 0.0008 | −8.38 | −5.83 ± 0.02, p < 0.0001 | −2.25 | −2.84 ± 0.3, p = 0.0001 | −2.45 −3.01 | ± 0.5, p < 0.0001 |
GBP1 | −9.93 | −5.27 ± 0.3, p = 0.0046 | −9.73 | −5.76 ± 0.73, p < 0.0001 | −7.03 | −7.22 ± 0.4, p = 0.0007 | −8.08 | −4.98 ± 0.52, p = 0.0018 |
CYP1B1 | 12.43 | 6.62 ± 0.11, p = 0.0009 | 13.83 | 13.49 ± 2.42, p = 0.0004 | 5.99 | 3.4 ± 0.75, p = 0.0008 | 9.19 | 5.29 ± 0.56, p = 0.0002 |
KCNMA1 | 7.09 | 4.7 ± 0.52, p < 0.0001 | 6.22 | 5.39 ± 0.8, p = 0.0004 | 7.7 | 4.62 ± 1.62, p = 0.0001 | 6.77 | 2.43 ± 0.2, p = 0.0004 |
CCNG2 | 2.52 | 3.64 ± 0.48, p = 0.0017 | 2.98 | 4.33 ± 0.31, p < 0.0001 | 3.51 | 5.3 ± 2.03, p = 0.0006 | 4.01 | 8.95 ± 1.6, p = 0.0028 |
HES1 | 2.80 | 5.81 ± 1.48, p = 0.0053 | 2.38 | 4.18 ± 0.19, p = 0.0006 | 2.67 | 4.88 ± 0.59, p = 0.0001 | 2.43 | 4.73 ± 0.62, p = 0.0078 |
Randomly selected genes showing differential pattern of expression by gene arrays (affy) were measured by quantitative real-time PCR (qRT-PCR) and showed fold change values consistent with gene arrays. QPCR values are mean ± s.e.m and the p values were calculated using two-tailed student's t-test.