Table 1.
Optimization of synthesis of 18F-labeled trans-cyclooctene
 | ||||
|---|---|---|---|---|
| Entry | Amount of 8 | Temp | Reaction Time | Radiochemical Yield |
| 1 | 100 μg (0.35 mM) | 75 °C | 15 min | 18% |
| 2 | 500 μg (1.8 mM) | 75 °C | 15 min | 25% |
|
| ||||
| 3 | 2.0 mg (7.0 mM) | 75 °C | 15 min | 71% |
|
| ||||
| 4 | 3.0 mg (11 mM) | 75 °C | 15 min | 71% |
|
| ||||
| 5 | 2.0 mg (7.0 mM) | 40 °C | 15 min | 24% |
|
| ||||
| 6 | 2.0 mg (7.0 mM) | 55 °C | 15 min | 34% |
|
| ||||
| 7a | 2.0 mg (7.0 mM) | 90 °C | 15 min | 71% |
|
| ||||
| 8 | 2.0 mg (7.0 mM) | 75 °C | 3 min | 43% |
|
| ||||
| 9 | 2.0 mg (7.0 mM) | 75 °C | 7 min | 68% |
|
| ||||
| 10 | 2.0 mg (7.0 mM) | 75 °C | 30 min | 71% |
a
Comparable results (70% RCY) were obtained under similar conditions using K2CO3/K222 instead of TBAB.