Table 3.
International prognostic model for initial salvage therapy in the relapsed/refractory setting76
| Factors | Points | ||
|---|---|---|---|
|
| |||
| Primary Site | Gonadal: | 0 | |
| Retroperitoneal: | 1 | ||
| Mediastinal | 3 | ||
|
| |||
| Response to 1st | CR/PR−: | 0 | |
| PR+/SD: | 1 | ||
| line | PD: | 2 | |
|
| |||
| Progression free | >3 mo: | 0 | |
| ≤3 mo: | 1 | ||
|
| |||
| Serum hCG level | ≤1000 IU/L: | 0 | |
| > 1000 IU/L | 1 | ||
|
| |||
| Serum AFP level | Normal: | 0 | |
| ≤1000 ng/ml: | 1 | ||
| >1000 ng/ml: | 2 | ||
|
| |||
| Liver, bone or | Absent: | 0 | |
| Present: | 1 | ||
|
| |||
| Add points to determine preliminary score (0–10). Then determine | |||
| category: 0 : 0; | 1–2 : 1; | 3–4 : 2; | ≥5 : 3 |
|
| |||
| Add histology points (below) to category score to determine final risk | |||
|
| |||
| Histology | Seminoma: −1 NSGCT / mixed: 0 |
||
|
| |||
| Risk Category | # of points | 2-year PFS | 3-year |
|
| |||
| Very low risk | −1 | 75% | 77% |
|
| |||
| Low risk | 0 | 51% | 66% |
|
| |||
| Intermediate risk | 1 | 40% | 58% |
|
| |||
| High risk | 2 | 26% | 27% |
|
| |||
| Very high risk | 3 | 6% | 6% |
Abbreviations: NSGCT: nonseminomatous germ cell tumor; CR: complete response; PR-: partial response with negative markers; PR+: partial response with positive markers; SD: stable disease; PD: progression of disease; hCG: human chorionic gonadotropin; AFP: alpha fetoprotein; PFS: progression free survival; FFS: failure free survival; OS: overall survival; DFS: disease free survival