Figure 3.

Clinical findings in family RP1459. (a, c) Fundus photographs and (b, d), fundus autofluorescence of left eye of patients II.2 (a, b) and II.1 (c, d) showing slight discoloration of fovea, loss of normal foveal reflex and moderate narrowing of retinal vessels (a, c) and alteration of the foveal retinal pigment epithelium (b, d). (e, f) OCT scans of left eye of patients II.2 (e) and II.1 (f) showing thinning of the retina with relative preservation of foveal photoreceptors. (g) Electroretinogram recordings showing the dramatic reduction of light-adapted responses of patients II.1 and II.2 with relatively conserved dark-adapted response of patient II.1, compared with normal responses in a control individual (normal) and to slightly decreased light-adapted responses in heterozygous carriers II.3, I.1 and I.2.