Figure 1.

The complex regulatory landscape of the genome. (A) DNA packaged into chromatin with regulatory proteins P300, transcription factors I and II, CTCF and histone modifications present. Underneath the chromatin fibre the position of genes and conserved elements, representing information that can be found in databases (e.g., UCSC, Ensembl). (B) The identification of accessible chromatin (DNAse I profile) and various chromatin marks (ChIP-seq) that are associated with regulatory elements yields a picture of a complex regulatory landscape.