Table 2.

ELISA microarray ANCOVA on smoking status and 3-nitrotyrosine levels for 24 plasma proteins.

Parametric ANCOVA model (n = 458)							Tukey’s adjusted p-values
Plasma proteins	Smoking status	Age	Sex (M > F)	BMI	N > E	N > Q	N > S	E > Q	E > S	Q > S
AGT		5.38E–15		0.935		0.047		0.972		0.274		< 0.001		< 0.001		0.007		0.002		0.858
AmR		1.10E–6		0.553		0.004		0.598		0.004		0.001		< 0.001		0.875		0.999		0.822
CD14		1.33E–8		0.827		0.047		0.742		0.043		< 0.001		< 0.001		0.790		0.586		0.950
CP		1.28E–10		0.943		0.004		0.338		0.026		< 0.001		< 0.001		0.680		0.191		0.546
CRP		2.95E–6		0.910		0.001		0.484		0.015		< 0.001		< 0.001		0.670		0.183		0.536
EGF		3.56E–7		0.748		0.003		0.484		0.018		0.091		0.005		0.526		0.972		0.581
EGFR		9.42E–10		0.782		0.017		0.614		0.031		< 0.001		< 0.001		0.993		0.950		0.979
E-Selct		5.25E–8		0.829		0.162		0.415		0.182		< 0.001		< 0.001		0.463		0.170		0.786
FGF		8.25E–7		0.336		< 0.001		0.946		0.003		0.017		< 0.001		0.428		0.940		0.563
Fibr		2.48E–11		0.816		0.007		0.376		0.024		< 0.001		0.001		0.810		0.277		0.526
HBEGF		5.14E–11		0.951		0.014		0.668		0.054		< 0.001		< 0.001		0.606		0.219		0.711
HGF		1.20E–7		0.987		0.007		0.766		0.002		0.003		< 0.001		0.611		0.979		0.659
ICAM		5.64E–9		0.522		0.005		0.806		0.035		< 0.001		< 0.001		0.933		0.856		0.989
IGF		1.41E–8		0.814		0.012		0.895		0.003		< 0.001		< 0.001		0.959		0.999		0.872
Leptin		1.24E–12		0.819		0.010		0.689		0.263		< 0.001		< 0.001		0.098		0.018		0.722
MMP1		2.75E–9		0.703		0.076		0.589		0.212		< 0.001		< 0.001		0.388		0.096		0.667
MMP2		1.51E–9		0.867		0.161		0.325		0.198		< 0.001		< 0.001		0.276		0.086		0.802
MMP9		3.30E–9		0.817		0.137		0.382		0.166		< 0.001		< 0.001		0.393		0.119		0.740
PDGF		1.01E–14		0.932		0.076		0.736		0.201		< 0.001		< 0.001		0.019		0.013		0.989
RANTES		8.83E–15		0.624		0.017		0.588		0.310		< 0.001		< 0.001		0.016		0.002		0.747
SP-A		7.07E–9		0.735		0.094		0.560		0.056		< 0.001		< 0.001		0.665		0.441		0.940
TGFα		2.16E–11		0.560		0.034		0.433		0.082		< 0.001		< 0.001		0.205		0.089		0.913
TNFα		2.42E–12		1.000		0.016		0.992		0.170		< 0.001		< 0.001		0.225		0.110		0.933
VEGF		4.12E–10		0.870		0.027		0.265		0.125		< 0.001		< 0.001		0.290		0.056		0.626
Abbreviations: AGT, angiotensinogen; AmR, amphiregulin; CD14, cluster factor 14; CP, ceruloplasmin; CRP, C-reactive protein; E, high risk for environmental smoke exposure; EGF, epidermal growth factor; EGFR, EGF receptor; E-selct, E-selectin; FGF, basic fibroblast growth factor; Fibr, fibrinogen; HBEGF heparin-binding EGF; HGF, hepatocyte growth factor; ICAM, intercellular adhesion molecule 1; IGF, insulin-like growth factor 1; MMP, matrix metalloprotease; N, never smokers; PDGF, platelet-derived growth factor A; Q, quitter or former smoker; RANTES, regulated upon activation, normal T-cell expressed, and secreted; S, current smoker; SP-A, surfactant protein A; TGFα, transforming growth factor α; TNFα, tissue necrosis factor α; VEGF, vascular endothelial growth factor.