Table 3.
Association of creatinine-corrected prenatal urinary concentrations of phthalate biomarkers on the infant MDI and PDI of the BSID-II at 6 months according to sex.
| Male (n = 211) | Female (n = 206) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | p-Value for interactionc | ||||||||||||||||||
| Biomarkersa | βb (95% CI) | p-Value | βb (95% CI) | p-Value | βb (95% CI) | p-Value | βb (95% CI) | p-Value | ||||||||||||||
| MDI | ||||||||||||||||||||||
| MEHHP | –1.41 | (–2.63 to –0.18) | 0.03 | –1.46 | (–2.70 to –0.22) | 0.02 | –088 | (–2.15 to 0.38) | 0.17 | –0.56 | (–1.87 to 0.75) | 0.40 | 0.27 | |||||||||
| MEOHP | –1.55 | (–2.82 to –0.29) | 0.02 | –1.57 | (–2.87 to –0.28) | 0.02 | –0.73 | (–2.04 to 0.57) | 0.27 | –0.43 | (–1.79 to 0.94) | 0.54 | 0.18 | |||||||||
| HHP+OHP | –1.58 | (–2.86 to –0.31) | 0.02 | –1.57 | (–2.86 to –0.28) | 0.02 | –0.69 | (–2.00 to 0.62) | 0.30 | –0.49 | (–1.85 to 0.86) | 0.47 | 0.21 | |||||||||
| MBP | –0.79 | (–1.68 to 0.10) | 0.08 | –0.93 | (–1.82 to –1.82) | 0.04 | –0.37 | (–1.31 to 0.57) | 0.44 | –0.21 | (–1.17 to 0.75) | 0.66 | 0.30 | |||||||||
| PDI | ||||||||||||||||||||||
| MEHHP | –2.00 | (–3.58 to –0.43) | 0.01 | –2.36 | (–3.94 to –0.79) | < 0.01 | –0.60 | (–2.24 to 1.04) | 0.47 | –0.29 | (–1.94 to 1.37) | 0.73 | 0.07 | |||||||||
| MEOHP | –1.63 | (–3.27 to 0.01) | 0.05 | –2.05 | (–3.71 to –0.39) | 0.02 | –0.37 | (–2.06 to 1.32) | 0.67 | –0.08 | (–1.79 to 1.64) | 0.93 | 0.11 | |||||||||
| HHP+OHP | –1.90 | (–3.53 to –0.27) | 0.02 | –2.28 | (–3.93 to –0.63) | 0.01 | –0.55 | (–2.24 to 1.15) | 0.52 | –0.16 | (–1.87 to 1.55) | 0.85 | 0.08 | |||||||||
| MBP | –1.02 | (–2.17 to 0.13) | 0.08 | –1.25 | (–2.40 to –0.11) | 0.03 | –0.51 | (–1.73 to 0.71) | 0.41 | –0.42 | (–1.63 to 0.78) | 0.49 | 0.30 | |||||||||
| Model 1: unadjusted. Model 2: adjusted for infant birth weight, maternal age, maternal education level, family income, breast-feeding, and residential area. aPrenatal maternal urinary concentrations were natural log-transformed. Urine samples with creatinine values > 20 mg/dL were used. bMDI or PDI scores per natural log change in micrograms per gram creatinine. cAdjusted for infant birth weight, maternal age, maternal education level, family income, breast-feeding status, residential area, infant sex, and the infant sex–phthalate interaction. | ||||||||||||||||||||||