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. 2011 Jun 10;119(10):1379–1383. doi: 10.1289/ehp.1103594

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PM-induced IL‑8 transcription is NF-κB dependent. BEAS-2B cells were transduced with lentiviral vectors encoding IL‑8wt-fLuc, IL‑8m^–NF-κB-fLuc, or NF-κBtr-fLuc before exposure to urban (U) PM₁₀ at 40 μg/cm² for 4 hr, TNFα (20 ng/mL) for 15 min, or media alone. Promoter activity was assessed by measuring levels of fLuc mRNA by RT-PCR. fLuc mRNA levels were normalized to EGFP mRNA levels, and results are expressed as fold change over untreated controls. Data are mean ± SE (n = 3). *p < 0.05.