Skip to main content
. 2011 Aug 10;36(13):2616–2628. doi: 10.1038/npp.2011.145

Figure 5.

Figure 5

GRM2/3−/− mice are hypoactive. (a) GRM2/3−/− mice (n=14) displayed less spontaneous locomotor activity (LMA) than wild-type mice (wt; n=18). (b) In all, 2.5 mg/kg amphetamine increased LMA in both wild-type (n=10) and GRM2/3−/− mice (n=10) mice, such that GRM2/3−/− mice remained hypoactive relative to wild-types. (i) Summarizes the total number of beam breaks over a 2-h period while (ii) shows the time course of changes in LMA. (c) In total, 10 mg/kg amphetamine induced stereotypy in both wt (n=6) and GRM2/3−/− (n=6) mice, resulting in a decrease in LMA followed later by an increase in activity levels relative to saline-injected controls (n=5 wt and n=6 GRM2/3−/− mice). At all-time points GRM2/3−/− mice were hypoactive relative to wild-types.