Figure 6.

Behavioral responses of MAO-A^Neo mice in the (a–i) elevated plus-maze and (j–l) light–dark box paradigms. (a–c) No significant differences were detected among genotypes in the percent entries in (a) open arms, (b) closed arms, and (c) center of an elevated plus-maze. (d–e) Similarly, no significant differences were found in the time spent in the (d) open arms and (e) closed arms of the apparatus. (f) MAO-A^Neo mice show a significantly lower duration on the central platform than MAO-A KO but not WT mice. (g) MAO-A^Neo mice showed an equivalent number of total entries as compared with WT and MAO-A KO mice. (h) Conversely, both MAO-A^Neo and MAO-A KO mice showed a reduction in stretch-attend postures (SAPs). (i) MAO-A KO mice engaged in significantly fewer head dips (HDs) than their WT and MAO-A^Neo counterparts. (j–l) In the light–dark box, all genotypes showed similar behavioral responses in the (j) time spent in the light compartment, (k) number of transitions between compartments, and (l) latency to enter the dark compartment. The values are represented as the mean±SEM. ^*P<0.05 and ^***P<0.001 compared with WT mice, and ^#P<0.05 compared with MAO-A^Neo mice.