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. 2011 Aug 31;36(13):2698–2709. doi: 10.1038/npp.2011.160

Figure 2.

Figure 2

Pan glucocorticoid receptor (GR) mRNA expression in the dorsolateral prefrontal cortex (DLPFC) in controls (green circles), and schizophrenia cases (blue triangles). (a) Schizophrenia diagnosis was a significant predictor (p<0.05) of pan GR mRNA expression in the regression model (F(2, 68)=21.12, p<0.0005). Comparison of the means of schizophrenia and control groups revealed an 11.4% decrease in pan GR mRNA expression in the schizophrenia cases relative to controls; (b) when included in multiple regression analysis, ‘suicide-negative schizophrenia' status was a significant predictor (p<0.005) of pan GR mRNA expression in the resultant regression model (F(2, 68)=24.98, p<0.0005). Comparison of their means revealed that the ‘suicide-negative schizophrenia' group (n=28) displayed 25.4% lower pan GR mRNA expression than the ‘suicide-positive schizophrenia' group (n=8), and 17.6% lower pan GR mRNA expression than controls. *p<0.05, **p<0.005.