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. 2011 Jul 15;10(14):2255–2262. doi: 10.4161/cc.10.14.16494

Figure 4.

Figure 4

Plk5 structure and the PBind motif. The murine Plk5 (as well as most other mammalian Plk5s) presents a full kinase domain although it lacks key T-loop activatory residues (See Fig. 2 for a comparison). The human PLK5 protein lacks almost the whole kinase domain due to the presence of a STOP codon. Both orthologs lack the main residues for phosphosubstrate recognition in the polo-box domain (PBD). Murine (not shown) and human PLK5 proteins display high sequence similarity in the PBind motif present in PLK2 and PLK3, but not in PLK1 (bottom alignment).