Table 2.
Simple and multivariate linear regression of LINE-1 methylation (%) and body composition in the North Texas Healthy Heart study, 2008a
| Simple linear regression (model 1) | Multivariate linear regression (model 2) | Multivariate linear regression (model 3) | Multivariate linear regression (model 4) | |
| β (95% CI) | β (95% CI)b | β (95% CI)c | β (95% CI)d | |
| Body mass index (kg/m2) | −0.12 (−0.58, 0.39) | −0.05 (−0.50, 0.40) | 0.05 (−0.40, 0.49) | 0.06 (−0.37, 0.50) |
| Waist circumference (cm) | −0.11 (−0.57, 0.35) | −0.04 (−0.49, 0.41) | −0.22 (−0.66, 0.22) | −0.20 (−0.64, 0.24) |
| Total adipose tissue (cm2) | −0.45 (−0.94, 0.05) | −0.37 (−0.87, 0.12) | −0.17 (−0.66, 0.31) | −0.16 (−0.65, 0.32) |
| Subcutaneous fat (cm2) | −0.65 (−1.14, −0.16) | −0.49 (−0.99, 0.01) | −0.23 (−0.75, 0.28) | −0.13 (−0.65, 0.38) |
| Visceral fat (cm2) | 0.20 (−0.30, 0.70) | 0.06 (−0.47, 0.58) | −0.02 (−0.50, 0.46) | −0.19 (−0.70, 0.31) |
| SAT/VAT ratioe | −0.70 (−1.19, −0.21) | −0.51 (−1.03, 0.01) | −0.19 (−0.74, 0.36) | 0.09 (−0.50, 0.68) |
| Percent fat mass (%) | −0.57 (−1.03, −0.11) | −0.50 (−0.98, −0.03) | 0.11 (−0.50, 0.69) | 0.11 (−0.48, 0.70) |
| Percent fat-free mass (%) | 0.57 (0.11, 1.03) | 0.50 (0.03, 0.98) | −0.11 (−0.69, 0.48) | −0.11 (−0.70, 0.49) |
| FM/FFM ratioe | −0.54 (−1.00, −0.08) | −0.48 (−0.95, 0.003) | 0.15 (−0.43, 0.73) | 0.13 (−0.45, 0.72) |
a
Body composition measures were standardized to mean of 0 and standard deviation of 1.
b
Adjusted for age and race/ethnicity (non-Hispanic white, non-Hispanic black and Hispanic).
c
Adjusted for age and gender.
d
Adjusted for age, gender and race/ethnicity (non-Hispanic white, non-Hispanic black and Hispanic).
e
SAT/VAT ratio is defined as the ratio of area of subcutaneous adipose tissue (cm2) to the area of visceral adipose tissue (cm2) at the L4-L5 interspaces; FM/FFM ratio is defined as the ratio of fat mass (%FM) to fat-free mass (%FFM).