Table 2.
Characteristic | Alzheimer's disease (n=48) | No dementia (n=1352) | Odds ratio (95% CI)
|
||
---|---|---|---|---|---|
Model 1* | Model 2* | Model 3* | |||
Systolic blood pressure (mm Hg): | |||||
<140 (normal) | 12 (25) | 606 (44.8) | 1.0 | 1.0 | 1.0 |
140-159 (borderline) | 20 (42) | 484 (35.8) | 2.1 (1.0 to 4.3) | 1.8 (0.85 to 3.7) | 2.1 (0.8 to 5.0) |
⩾160 (high) | 16 (33) | 262 (19.4) | 3.1 (1.4 to 6.6) | 2.3 (1.0 to 5.0) | 2.8 (1.1 to 7.2) |
Diastolic blood pressure (mm Hg): | |||||
<90 (normal) | 21 (44) | 704 (52.1) | 1.0 | 1.0 | 1.0 |
90-94 (borderline) | 9 (19) | 289 (21.4) | 1.0 (0.47 to 2.3) | 1.1 (0.48 to 2.4) | 1.4 (0.6 to 3.5) |
⩾95 (high) | 18 (38) | 359 (26.6) | 1.7 (0.88 to 3.2) | 1.6 (0.84 to 3.2) | 1.7 (0.8 to 3.6) |
Cholesterol concentration (mmol/l): | |||||
<6.5 (normal) | 11 (23) | 630 (46.6) | 1.0 | 1.0 | 1.0 |
⩾6.5 (high) | 37 (77) | 722 (53.4) | 2.9 (1.5 to 5.8) | 2.7 (1.4 to 5.4) | 2.2 (1.0 to 4.7) |
Risk groups I:† | |||||
Single risk factor | 23 (48) | 660 (48.8) | 1.0 | 1.0 | 1.0 |
Combined | 15 (31) | 162 (12.0) | 2.7 (1.4 to 4.4) | 2.2 (1.1 to 4.4) | 3.5 (1.6 to 7.9) |
Risk groups II:† | |||||
Single risk factor | 13 (27) | 614 (45.4) | 1.0 | 1.0 | 1.0 |
Combined | 30 (63) | 427 (31.6) | 3.3 (1.7 to 6.4) | 2.9 (1.5 to 5.7) | 2.8 (1.3 to 5.9) |
Model 1 gives univariate odds ratios for the risk of Alzheimer's disease; model 2 controls for age and body mass index; model 3 controls for age, body mass index, education, history of myocardial infarction and cerebrovascular symptoms, smoking status, and alcohol consumption.
In risk groups I, single risk factor indicates either systolic blood pressure ⩾160 mm Hg or cholesterol ⩾6.5 mmol/l, and combined indicates both of these risk factors. Risk groups II were similar, but the cut-off point for systolic blood pressure was 140 mm Hg.