Table 2. Results of functional enrichment analysis.

CpGO/E class	GO term	EASE score	Benjamini
low	Metabolism	<0.01	<0.01
	Protein transport	<0.01	0.04
	Intracellular protein transport	<0.01	0.09
	Biosynthesis	<0.01	0.15
	Electron transport	<0.01	0.23
high	Transport	<0.01	<0.01
	Carbohydrate metabolism	<0.01	<0.01
	Proteolysis and peptidolysis	<0.01	<0.01
	Chitin metabolism	<0.01	<0.01
	Muscle development	<0.01	0.03

For both low and high CpG_O/E gene populations, the five most overrepresented GO terms are presented. The EASE score is a modified Fisher exact probability p-value, the Benjamini value is the raw EASE score corrected for multiple comparisons using the Benjamini- Hochberg false discovery rate method [72]. Significantly overrepresented functional categories (p<0.05) are shown in italics.