Table 5. Multiple Cox regression analyses showing factors independently associated with incident prediabetes.
| Incident prediabetes | ||||||
| Risk factors | Model 1b | Model 2c | Model 3d | |||
| HR (95%CI) | Adjusted P | HR (95%CI) | Adjusted P | HR (95%CI) | Adjusted P | |
| E23K (KK) | 1.18 (1.02–1.35) | 0.021 | 1.15 (1.00–1.32) | 0.048 | 1.15 (1.00–1.33) | 0.051 |
| Age (years) | 1.03 (1.03–1.04) | <0.001 | 1.03 (1.02–1.04) | <0.001 | 1.04 (1.03–1.05) | <0.001 |
| Sex (Male) | 1.15 (0.95–1.40) | 0.157 | 1.01 (0.83–1.23) | 0.922 | 1.03 (0.84–1.25) | 0.793 |
| BMI (kg/m2) | 1.07 (1.04–1.10) | <0.001 | 1.05 (1.02–1.08) | 0.001 | 1.07 (1.04–1.10) | <0.001 |
| FPG (mmol/l) | 1.95 (1.51–2.53) | <0.001 | 1.65 (1.26–2.16) | <0.001 | - | - |
| 2 hrG (mmol/l) | - | - | 1.51 (1.37–1.67) | <0.001 | - | - |
| HOMA-IRa | - | - | - | - | 1.22 (1.02–1.45) | 0.029 |
a
Natural-log-transformed before analysis.
b
Model 1: Multiple adjustments made for age, sex, BMI and fasting glucose.
c
Model 2: Multiple adjustments made for age, sex, BMI, fasting glucose and 2-hr glucose.
d
Model 3: Multiple adjustments made for age, sex, BMI and HOMA-IR.
BMI: Body mass index; FPG: Fasting plama glucose; 2 hrG: 2 hr post-OGTT glucose; HOMA-IR: homeostasis model assessment index for insulin resistance; HR: Hazard ratio; CI: Confidence interval; P: P-value.