Table 1.

Effects of high cholesterol diet and IK17-Fab or IK17-scFv on weight and lipid profiles.

Study Time Course	− 4 week (21% fat/1.25% chol diet)		− 2 week (0.5 % HC- diet)		0 week (Intervention start)		4 week		8 week		14 week (Endpoint)
Experimental Groups (n=11)	IK17- Fab	Control	IK17- Fab	Control	IK17- Fab	Control	IK17- Fab	Control	IK17- Fab	Control	IK17- Fab	Control
Weight (gram) ± SEM	17.7 ± 0.6	17.9 ± 0.4	24.2 ± 0.5	23.5 ± 0.4	24.9 ± 0.6	24.1 ± 0.4	27.0 ± 0.6	25.0 ± 0.5	28.0 ± 0.7	26.5 ± 0.5	30.3 ± 0.8	28.0 ± 0.5
Total Cholesterol (mg/dl) ±SEM	327 ± 9.6	337 ± 8.3	1420 ± 75.7	1532 ± 50.3	734 ± 24.3	752 ± 24.6	612 ± 25.3	676 ± 33.8	640 ± 30.2	654 ± 40.3	629 ± 43.9	536 ± 23.1
Triglyceride (mg/dl) ±SEM	201 ± 11.3	173 ± 7.3	410 ± 51.7	372 ±45.2	126 ± 6.8	109 ± 7.8	117 ± 9.5	130 ± 13.4	98 ± 7.9	104 ± 11.1	190 ± 30.3	145 ± 9.0

Study 2 Time Course	−2 week (Baseline)		8 week (Midpoint)		16 week (Endpoint)
Experimental Groups (n)	Adv-IK17-scFv (13)	Adv-EGFP (15)	Adv-IK17-scFv (13)	Adv-EGFP (15)	Adv-IK17-scFv (13)	Adv-EGFP (15)
Weight (gram) ± SEM	23.9 ± 0.4	24.1 ± 0.6	23.6 ± 0.5	24.1 ± 0.5	23.0 ± 0.7	23.7 ± 0.6
Total Cholesterol (mg/dl) ± SEM	187 ± 3.3	200 ± 6.5	984 ± 41.6	1010±46.8	741 ± 44.8	831 ± 35.9
Triglyceride (mg/dl) ± SEM	87 ± 5.0	89 ± 3.4	71 ± 6.3	85 ± 6.8	104 ± 15.5	91 ± 7.8

Weight, total cholesterol (TC) and triglyceride (TG) depicted are at the beginning of the diet period. In Study 1, 21% milkfat/1.25% cholesterol diet started at −4 week and switched to 0.5 % HC-diet at −2 week before the infusion of IK17-Fab (0 week); In study 2, adenovirus gene therapy started one week before 1.25 % HC-diet feeding (0 week). Data are expressed as mean ± SEM. No statistically significant differences were noted in total cholesterol levels between groups at each timepoint in both studies.