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Senescent cells, by virtue of their SASP, may promote both the degenerative and neoplastic diseases of aging. Both senescent cells and preneoplastic cells increase with age in many tissues. The SASP of senescent cells can cause normal cells within tissues to lose optimal function, leading to tissue degeneration. The SASP can also cause premalignant cells to proliferate and adopt more malignant phenotypes, leading to full-blown cancer.
