Figure 8. Stapedial defects are present in the majority of Chd7^Gt/+ mice.

(A) Ventro-lateral in situ view of the stapes (s) and incus (i) from a Chd7^Gt/+ mouse demonstrating ankylosis of dorsal crus of stapes to the dorsal wall of the middle ear space (arrow). (B) Excised stapes and part of the dorsal wall, in anterior view from a Chd7^Gt/+ mouse, showed a thick connection between the dorsal crus and the wall (arrow) and flattened footplate (f). (C) Normal stapedial anatomy of a wild type stapes with bowed footplate and arched ventral crus (v). The arrow in each panel indicates the insertion site of the stapes muscle tendon. Other abbreviations: (co) cochlea, (sa) stapedial artery, (c) capitulum of stapes. Scale bars = 0.5 mm.