Figure 3. Increased doxorubicin uptake and efficacy under alkaline conditions.
(A) Intracellular pH measurements and (B) doxorubicin uptake were determined as a function of extracellular medium pH in MCF-7 cells. (C) The effect of doxorubicin toxicity on MCF-7 cells in-vitro as a function of extracellular medium pH. (Adapted from Mahoney et al., Biochemical Pharmacology 25)