Table 3.
Local Cluster-Level Maxima of Blood-Oxygen-Level-Dependent fMRI Signal Change in Frontal Cortex During the Cue and Delay Period of the Reorder minus Rehearse Working Memory Task in Healthy Comparison Subjects and Patients With Schizophrenia
Estimated | Coordinates2 | ||||
---|---|---|---|---|---|
Group and Region | Brodmann’s Area | Z Score1 | x | y | z |
Comparison subjects (n=19) | |||||
Left Middle Frontal Gyrus3 | 46 | 3.55 | −43 | 31 | 20 |
Right Middle Frontal Gyrus3 | 9 | 3.36 | 49 | 29 | 30 |
Left Middle Frontal Gyrus | 6 | 3.12 | −24 | 2 | 53 |
Patients (n=20) | |||||
Left Middle Frontal Gyrus3 | 46 | 3.63 | −45 | 42 | 18 |
Right Middle Frontal Gyrus3 | 9 | 3.63 | 49 | 35 | 30 |
Controls minus Patients | |||||
No above-threshold differences | -- | -- | -- | -- | -- |
Patients minus Controls | |||||
Right Medial/Superior Frontal Gyrus | 10 | 3.73 | 16 | 51 | 9 |
Left Middle Frontal Gyrus | 10 | 3.18 | −34 | 56 | 20 |
Note:
Peak activation in a cluster of seventeen voxels in which the difference in signal change exceeded a cluster-corrected p-value of 0.05;
Coordinates from the stereotaxic atlas of Talairach and Tournoux (1988);
Functional regions of interest (ROIs) used in correlational analyses.