Copper sulfate (A-B) and cimetidine (C-D) provided some protection to hair cells when co-administered with cisplatin. The mean number of surviving hair cells was counted for cochlear explants (n=6 per condition) exposed for 48 h to 10 μM (A, C) or 50 μM (B, D) cisplatin, the combination of cisplatin plus copper sulfate (CuSO4; 10, 50 or 100 μM) (A,B), or the combination of cisplatin plus cimetidine (10, 100 or 2000 μM) (C,D).